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On the other hand, strict glucose control does not limit or improve the damage caused by diabetes and its comorbidities to the CNS [17, 18] as the impact of insulin resistance, obesity, and diabetes on the CNS begins very early in the natural history of the disease [19]

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If dietary measures are insufficient, over-the-counter fiber supplements (psyllium, methylcellulose) or osmotic laxatives (polyethylene glycol) may be appropriate after discussing with your healthcare provider

Corresponding EHR data for UKBB participants were sourced from the UK Biobank Resource, which operates under the auspices of the UK Biobank Steering Committee and has received ethical approval from the North West Multi-centre Research Ethics Committee