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This molecular signature correlated with dose-dependent increases in intracellular ROS and significant DNA damage in larval haemocytes
392,393 Iron accumulates in the parenchymal cells of various organs in HH patients, generating ROS through the Fenton reaction, resulting in ferroptosis and several serious chronic complications, including heart disease, diabetes, and cirrhosis
The cages of these mice were covered with black paper except for the lid, and to minimize contact, the mice were only taken out of the cage once a week by one person to clean the cage 48,49