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To avoid any potential confounding effect of the duration of statin therapy on study findings, we a priori stratified patients according to previous statin therapy YES or NO

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4.4 Inhibition of glycolysis MG blocks tumor cell energy metabolism by directly inhibiting key enzymes of glycolysis (e.g., GAPDH) and interfering with the function of mitochondrial respiratory chain complex I, leading to energy depletion in cancer cells and triggering apoptosis (120123)

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