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Most common incretin-based therapies and their mechanism of action, impact on glycemic control, weight, and specific evidence in MASLD Incretin-based therapies provide multiple metabolic benefits beyond weight loss, including improved -cell function, enhanced lipid metabolism, cardiovascular and renal protection, and anti-inflammatory effects [105,106]

After weighting the cohorts for inverse probability of treatment, the researchers found that, compared with second-line GLDs, ADRD risk was significantly lower with both GLP-1 receptor agonists (adjusted HR = 0.67