References Marino F, Salerno N, Scalise M, Salerno L, Torella A, Molinaro C et al (2023) Streptozotocin-induced type 1 and 2 diabetes mellitus mouse models show different functional, cellular and molecular patterns of diabetic cardiomyopathy
However, by replacing arginine with threonine, the ECL2 of GLP-2R is no longer able to dip into the receptor core and becomes distant from the N-terminal histidine of GLP-2
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The therapeutic implications were obvious: if you could block myostatin in a person on purpose, you might be able to rebuild muscle lost to dystrophy, aging, or as it turns out weight-loss drugs
