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Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025

Systemic side effects are not well-documented in human studies at therapeutic doses

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PL-14736 Amino-acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Molecular formula (free base): C 62 H 98 N 16 O 22 Molecular weight (free base): ~1,419.5 g/mol CAS: 137525-51-0 Form: Lyophilised powder Appearance: White to off-white solid Handling & storage Storage (dry): Keep vials protected from light and moisture