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Is it possible we are missing a treatment effect of Lixisenatide because of the heterogeneity present in most Parkinsons groups recruited for clinical trials (in other words Parkinsons is not one disease and we may have recruited a few different subtypes and this watered down the potential effects)

Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs

Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice