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These medications mimic the incretin hormone glucagon-like peptide-1, which plays a central role in appetite regulation, insulin secretion, and gastric emptying

In the subsequent Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) study of alogliptin there was no statistically significant difference in HF hospitalisation (3.9% vs 3.3% with placebo) [59], and in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), the rate of hospitalisation for HF was 3.1% in both sitagliptin- and placebo-treated patients [60]

Zhu J, Li X, Yin J, Hu Y, Gu Y, Pan S

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