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So 50 units is 0.5 mL and 25 units is 0.25 mL

When KCNB1 (a homolog of KVS-1) contacts with ROS, Src/JNK-meditated apoptotic program in mitochondria would be initiated to produce more ROS ( 2+ channel, would open more readily and thus, leak Ca 2+ after oxidation ( 2+ by activating inositol 1,4,5-trisphosphate receptors (IP3R) to open the permeability transition pore, thereby changing the permeability of mitochondria to further release more ROS as a vicious cycle ( Furthermore, Pt-induced ROS production can also promote the secretion of proinflammatory cytokines, for example, TNF-, interleukin-1 (IL-1), interleukin-6 (IL-6), chemokine ligand 2 (CCL2), and so on ( Overall, the accumulation of Pt drugs in the DRG intensifies DNA damage and ROS production

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