does glp 1 cause insulin resistance GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous GLP-1 production and L-cell differentiation | Diabetology & Metabolic Syndrome Blood Glucose Levels: Genetics and

And clinically meaningful weight loss, defined as 5% or more of body weight, usually takes 12-16 weeks at therapeutic doses

The primary risk is compounded stomach slowness leading to bloating, nausea, or acid reflux

Week 2 on GLP-1s: Stabilizing Side Effects and Building Healthy Habits During week 2, most patients adjust to GLP-1 medication and start noticing more consistent appetite changes

Weight Loss While weight loss is often a desired effect of GLP-1 drugs, it can sometimes be excessive or rapid, leading to: Nutritional deficiencies Gallstones Muscle loss Monitoring weight and nutritional intake is important to ensure that weight loss remains within healthy limits