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The positive results of oestrogen therapy in animal PD models provide more evidence supporting this hypothesis (Gillies and McArthur, 2010)

The delivery label alone is not enough

Moreover, a multicentric, double-blind, placebo-controlled, randomized trial that used the same methodology found that in patients who are suffering from stage I or II HNSCC and on radiation therapy while taking 400 IU of -tocopherol daily had a significantly higher incidence of subsequent primary malignancies (60/1000 person-years) compared to those on placebo (25/1000 person-years)