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But alongside these celebrated benefits, a more complicated conversation has started to surfaceone that isnt about body fat, blood sugar, or the number on the scale

The relevance of this observation extends to the wider family of GPCRs, with individual effects almost certainly receptor-specific, as both -arrestin-biased 54 and G protein-biased 55 ligands have proved effective for individual receptors in preclinical studies

A recent survey finds that 1 in8 people in the United States have taken one of these medications for weight loss, 6 in 10 of whom were people with diabetes or cardiovascular disease

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