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Tirzepatide is a lipidated 39-amino-acid polypeptide

Since higher levels of glutamate were observed in FR rats, we cannot exclude that the concomitant increase of GABA amount may represent a compensatory mechanism to prevent possible dysfunction related to concomitant quantitative changes of its precursor

To determine whether these transcriptomic changes were reflected at the metabolic level, we quantified -hydroxybutyrate, a terminal product of -oxidation, in both cell lysates and culture supernatants

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