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While selective activation of PPAR by fibric acid derivates (fibrates) primarily improves hepatic lipid and cholesterol metabolism 3 , the selective activation of PPAR by thiazolidinediones (TZDs) enhances insulin sensitivity in peripheral tissues such as the adipose tissue, liver and skeletal muscle 4

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10.1016/j.bbapap.2014.11.008 150 SkopelitouK.MuletaA

In the fetal stages, the trajectories and PAGA connectivity graph showed predominant involvement of proximal progenitors in early enterocyte development, a feature identified in various scRNA-seq studies 16,30,39