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Common side effects The most common side effects of Trulicity include nausea, diarrhea, vomiting, abdominal pain and decreased appetite, indigestion, and fatigue

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Health Canada approval typically follows FDA approval by 6-18 months

Serotonin stimulates the 5-HT 3 receptor to release acetylcholine in the nerve ends, which causes smooth muscle contraction and enhanced intestinal secretion ( 3 receptor antagonists which inhibit the 5-HT 3 receptor activation on the mucosal processes of the primary afferent neurons, and reduce activity of the secretory and motor reflex, by inhibiting the submucosal plexus and myenteric plexus respectively (Figure 2)