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Orforglipron side effects The most common adverse events in orforglipron trials were gastrointestinal: nausea, diarrhea, constipation, and vomiting

Some patients find that remaining at a lower maintenance dose, whilst potentially sacrificing some glycaemic or weight loss benefits, provides an acceptable balance between efficacy and tolerability

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To further investigate the mechanisms by which GLP-1R agonist pharmacotherapy alters midbrain neuron activity and attenuates cocaine seeking, we used FISH to phenotype GLP-1R-expressing cells in the VTA