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68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components

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Semaglutide therapy has become a cornerstone of modern weight loss treatment, with studies showing sustained body weight reduction of 10-22% over 68 weeks in clinical trials

Initially, these medications were developed for the treatment of type 2 diabetes mellitus, but GLP-1 RA drugs have demonstrated remarkable outcomes in clinical settings