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As previously mentioned, immune cells typically lack mechanisms to adapt to nutrient competition, which is a major mechanism regulating anti-tumor immunity

Additionally, it modulates inflammasome activation, such as suppressing NLRP3 inflammasome assembly, to reduce inflammatory cytokine release and alleviate hepatic inflammation

The SURMOUNT-5 data showing lower discontinuation rates with tirzepatide (2.7% versus 5.6%) is encouraging but not a guarantee

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