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Blood thinners like warfarin, heparin, and newer anticoagulants significantly extend bleeding time from any vessel damage

The separate TRANSCEND-T2D Phase 3 program covers type 2 diabetes (TRANSCEND-T2D-1 reported topline results March 19, 2026)

Patients planning surgery should discuss tirzepatide with their healthcare team, though recent guidance from the American Society of Anesthesiologists indicates most patients can continue GLP-1 receptor agonists perioperatively, with modifications only for those at high risk of gastrointestinal complications

For patients and providers, this means tirzepatide may be a better option for those seeking the greatest possible weight reduction or who have not achieved their goals with a GLP-1 agonist alone