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Having assessed the relevance of the three C-terminal serine doublets on the phosphorylation of the receptor in response to agonist stimulation, we next investigated the effect of mutating each doublet to alanine on the capacity of the receptor to traffic to the plasma membrane and therefore be available for agonist binding, as well as its propensity to undergo agonist-induced endocytosis in INS-1 832/3 GLP-1R KO cells
Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options
You might find that a dose of aspirin that used to work in thirty minutes now takes an hour or more to provide relief
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