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The recommended schedule from clinical trials is: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly Week 21+: 15 mg once weekly (maximum dose) Not everyone follows this exact schedule

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Magnesium and Zinc Researchers have found that high doses of zinc supplements can decrease magnesium absorption and affect magnesium balance in the body, regardless of calcium intake

Not the I had a busy day kind of fatigue, but persistent tiredness that does not improve with rest