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Rapid Drop in Blood Sugar or Caloric Intake Retatrutide can sharply reduce appetite, leading to: Low caloric intake Low blood sugar (even in non-diabetics) Electrolyte imbalance These metabolic changes can trigger symptoms very similar to anxiety: Racing heart Shakiness Restlessness A sense of being on edge 2

This is why doctor approval and monitoring are essential for both starting and continuing the treatment

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It has been estimated that the amount of GLP-1 secreted after ingestion of a single nutrient load (calculated as integrated incremental response multiplied by the known metabolic clearance rate for GLP-1) accounts for about 10 % of the GLP-1 content of jejunal L-cells [46]