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Quick Answer: GLP-1 receptor agonist-related fatigue likely results from multiple indirect mechanisms including substantial caloric restriction, gastrointestinal side effects causing dehydration and nutritional deficits, and metabolic adaptation during weight loss, rather than a single direct pharmacological effect

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Non-peptidic oral GLP-1RAs may eventually reduce supply pressures because they do not require peptide synthesis or cold-chain storage, but this will depend on scalable, cost-efficient manufacturing pathways