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Of note, the relative abundance of the Parasutterella genus, which was significantly enriched in both the vehicle- and 5A-1MQ-treated animals transitioned from WD to LD compared to both the WD and LD control groups, was observed to be significantly correlated (either positively or negatively) with 30 EWAT metabolites, both with and without outliers included

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When activated, these receptors can dampen dopamine signaling in pathways linked to substance use reinforcement

Tirzepatide has an additional, lower-frequency side effect dysesthesia (unusual sensations) linked to GIP receptor activity