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RESULTS Patient Population The final study sample included 2168 patients ( Supplementary Figure S1 )

Together, these findings underscore that LC's variable clinical efficacy arises from interacting factors including patient phenotype, dosing strategy, intervention duration, and endpoint sensitivity

Given the degree of irreversible neurodegeneration by the time many patients are enrolled, it was always a difficult hill to climb. After the findings were released, Novo Nordisk announced it would discontinue a planned one-year extension of the trials

These aren't Ozempic-specific guidelines from Novo Nordisk they're adapted from the broader FDA framework for anti-obesity pharmacotherapy