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Npj Metabolic Health and Disease, 3 (1), 26

Because it is an essential, non-covalent cofactor for the Pyruvate Dehydrogenase (PDH) and Alpha-ketoglutarate dehydrogenase (KGDH) complexes, supplementing with highly bioavailable ALA helps unblock the stalled Krebs cycle

doi: 10.1016/j.biomaterials.2021.120944 122 GaspariTLiuHWelungodaIHuYWiddopREKnudsenLBet al

For example, these mediators, increase RANKL expression in stromal/osteoblastic cells or by sensitizing precursors to RANKL stimulation ( Estrogen plays a critical regulatory role in osteoclastogenesis primarily through modulation of the RANKRANKL signaling pathway