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doi: 10.1002/ejp.621 7 BurgunderJ

A critical consequence of inflammation-induced erythrocyte membrane damage is the externalization of PSa phospholipid normally confined to the inner leaflet of the erythrocyte membrane

[4] The second activation step takes place predominantly in the kidneys where 1-hydroxylase converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol), an active secosteroid hormone that binds nuclear receptors in enterocytes, osteoblasts, renal tubules, parathyroid cells, and numerous immune and endocrine cells to modulate hundreds of genes involved in calcium-phosphate homeostasis, skeletal remodelling, and immunoregulation

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