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Many organs and tissues express vitamin D receptors, suggesting that vitamin D affects physiological functions beyond its role in maintaining bone health [1,2,3] and is crucial for the regulation of numerous important genes [4]

Meanwhile, the prevention of transmission and virus proliferation, as well as palliatives against HIV-derived diseases plays a crucial role

Among these, C-X-C chemokine receptor type 4 (CXCR4, also known as CD184) is a G protein-coupled receptor that interacts with its ligand CXCL12 to activate key signaling pathways, including the PI3K/AKT, JAK/STAT, Hedgehog, and ERK1/2 pathways, which are essential for promoting tumor progression, metastasis, and maintenance of the CSC phenotype

doi: 10.1016/j.bbagen.2012.10.012 199 Mosquera-SulbaranJ