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Emerging therapeutic strategies targeting lactate metabolism, including glycolytic inhibition, lactate transporter blockade, combination with immune checkpoint inhibitors, and epigenetic modulation, such as Kla enzyme inhibitors, could potentially aid in subverting the immunosuppressive TME, augmenting immune infiltration, and potentiating chemotherapeutic efficacy (22, 23)

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When you climb into bed, your body should recognize the signal and automatically begin the transition toward sleep