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After matching and excluding patients with ESRD, the number of patients using GLP1Ra was 554 and those who never used GLP-1Ra was 518

In June 2026 the MHRA approved oral semaglutide, marketed as the Wegovy pill , the first oral GLP-1 receptor agonist licensed in the UK for weight management

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Nevertheless, the integration of two-year outcomes, rigorous propensity matching, millions of clinical notes analyzed through validated AI models, and one of the largest GLP-1RA-treated cohorts studied to date provides a robust characterization of real-world treatment heterogeneity