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Two-way analysis of variance (ANOVA) or Multiple unpaired t tests were used for comparison between multiple groups, the Tukeys multiple comparisons or Holm-dk tests were used to correct the p -values for each group, respectively

Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

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The interaction requires attention: tirzepatide slows gastric emptying, which can affect levothyroxine absorption timing and completeness