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Patients who reach 2.4 mg and do not experience adequate response typically benefit more from combined therapy or alternative medications than from further dose escalation

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These positive effects on weight loss together with the experimental evidence suggesting that liraglutide exerts its effects directly in the CNS raise the question of whether GLP-1RAs of higher molecular weights, such as dulaglutide and albiglutide, would be as effective as liraglutide in promoting weight loss [23]