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Microglia can influence neuronal firing through activity-dependent release of pro-inflammatory mediators and neuromodulatory factors, including cytokines and neurotrophic signals that regulate synaptic strength and network excitability (Klapal et al., 2016)

The follow-up period for each participant began from the baseline date and continued until the earliest occurrence of one of the following events: a new osteoporosis diagnosis, loss to follow-up, death, or the end of the study period

These vitamins can minimize birth defects as well as help in relieving some common symptoms

GPNMB expression was also increased in senescent human umbilical vein endothelial cells, in endothelial cells from old mice, and in several other tissues such as bone marrow and lungs 62 , suggesting that GPNMB could be a potential target in senescence-related pathological conditions