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Ankylosing spondylitis causes inflammatory back pain that worsens with rest and improves with movement, unlike typical mechanical back pain The HLA-B27 gene is present in about 8590% of people with AS, though carrying it doesn't guarantee developing the condition Morning stiffness lasting 30 minutes or longer is a hallmark symptom that distinguishes AS from other causes of back pain Early diagnosis through MRI and blood tests can help slow or limit spinal fusion and disability progression Treatment combines medications, physical therapy, and lifestyle changes to maintain mobility and reduce inflammation Back pain affects millions of people, but a specific type of chronic spinal inflammation called ankylosing spondylitis causes suffering that most people never recognize

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Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans