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While these effects may be beneficial in selected cardiovascular indications, they raised concerns regarding hypotension and hemodynamic instability when considered for chronic metabolic disease
Contact your GP, trial team, or seek urgent medical care if you experience any of the following: Diarrhoea lasting more than seven days without improvement Blood or mucus in the stool, which may indicate colitis or another serious gastrointestinal condition Signs of dehydration, including dizziness, reduced urine output, dry mouth, or confusion particularly in older adults or those with diabetes
Nixon 4 , Marie-Elaine Nixon 4 , Gillian Ingram 5 , John R
Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years
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