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When in the reduced state, GSH is active and protects cells and DNA by neutralizing reactive oxygen species, such as naturally occurring peroxides and free radicals produced during metabolism that could otherwise damage cellular components

Measurement of O2 evolution from H2O2 decomposition Inhibition of cytochrome c reduction by superoxide generated from xanthine oxidase Direct measurement of GSH oxidation to GSSG Measurement of hydroxyl radical formation via Fenton reaction Correct Answer: Inhibition of cytochrome c reduction by superoxide generated from xanthine oxidase Q8

10.1038/s41538-023-00245-8 91 RauS.GreggA.YaceczkoS.LimketkaiB

Additional studies are needed to definitively examine the role of Txnrd1 during ferroptosis in PTC cells