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Table of Contents How B12 Deficiency Can Affect HbA1c Test Results Why HbA1c May Be Unreliable in B12 Deficiency Who Is Most at Risk of Both B12 Deficiency and Diabetes UK Guidance on Interpreting HbA1c Alongside B12 Status When to Retest HbA1c After Treating B12 Deficiency Talking to Your GP About B12 and Blood Sugar Monitoring Frequently Asked Questions How B12 Deficiency Can Affect HbA1c Test Results B12 deficiency disrupts red blood cell maturation, producing fewer, larger cells with an altered lifespan that can make HbA1c results spuriously high or low

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However, both of them have limited human studies and the majority of what we know about them is derived from published animal studies

Folate and B12 from the microbiome: One connection is that the gut microbiome supplies part of our daily requirement for folate and vitamin B12, both of which are important in the methylation cycle and the regeneration of homocysteine to methionine