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Which approach is right, or whether each suits a different patient group, is an open question the field will not resolve quickly

Glucagon-like peptide-1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial

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Instead of directly targeting mood chemicals in the same way as traditional antidepressants, GLP-1 RAs seem to influence mood through pathways related to appetite, reward, and inflammation