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The gut microbiome, as the second genome, plays an important role in dynamically integrating signals from the host and its environment, impacting both physiological homeostasis and disease emergence ( Changes in gut microbiota alter the production of gut metabolites and thus affect the development of CVDs ( Although the role of TMAO in CVDs is well established, detailed understanding of how TMAO regulates the development and progression of CVDs has yet to be elucidated

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There are multiple amylins in phase II trials, including Amycretin (another dual amylin/GLP-1 agonist, Novo Nordisk) and Eloralintide (a single-target amylin analogue, Eli Lilly)

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