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5 Renal targeting challenges and novel approaches The complexity of the kidney, including diverse cell types and structural components, complicates efforts to protect and restore renal function, while challenges in developing effective drug delivery systems for renal diseases are widely acknowledged [73]

By age 40, humans lose about 1% of their skin collagen each year

While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking