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The core machinery of this axis is the IP3R-GRP75-VDAC1 tripartite complex, where GRP75 (Szabadkai et al., 2006) acts as a linker protein that physically bridges the IP3R on the ER (Rapizzi et al., 2002), funneling ions directly into the mitochondrial matrix (Szabadkai et al., 2006)
Wrinkles, loss of volume and a loss of elasticity become noticeable after the age of 25
Expression of the antiangiogenic factor 16K hPRL in human HCT116 colon cancer cells inhibits tumor growth in Rag1 mice
Cancers 14 , 4959 (2022)
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