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The trials lasted between 8 and 48 months and used dosages ranging from 140 mg to 2,100 mg of silymarin daily, with most trials using a daily dosage of 280 mg

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The 400 m distanced walked was determined by conducting a validated 6-min walk test [29] and QoL using RAND SF-36 questionnaire

Readers should consult qualified professionals and comply with all applicable UK regulations when conducting research involving investigational peptides.