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10.1210/clinem/dgae917 J Clin Endocrinol Metab

However, emerging evidence suggests that targeting adipose tissue inflammation, lipid metabolism and hormone signalling pathways may represent promising avenues for future therapeutic development, including pharmacological approaches using PPAR- and ER antagonists, probiotics and epigenetic regulators [403, 404]

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It reduces the accumulation of reactive oxygen species (ROS) and downregulates the expression of Interleukin 6 (IL-6) gene which upregulates a transcription factor known as STAT3