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The key principles include: Protein Priority: Maintain 1.6-2.2 g/kg protein to preserve lean mass, especially when appetite is suppressed by GLP-1 agonists

"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

Recent regulatory changes and future outlook The regulatory landscape is evolving

Antioxidant and anti-inflammatory activity: GHK-Cu is a powerful modulator of oxidative stress