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Furthermore, the increased reduction in the abundance of GPx3 in unaffected siblings of children with stage 3 as compared to children with a stage 1 sibling with the disease suggests that GPx3 levels may serve as an indicator for individuals within one household most at risk for developing the severe form of disease
Data availability The datasets generated and analyzed during the current study are not publicly available due to participant privacy concerns but are available from the corresponding author on reasonable request
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Methods A targeted literature search of experimental and clinical studies was performed, focusing on angiogenesis-related mechanisms in neurodegeneration and the effects of antiangiogenic compounds on neuronal and vascular function
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