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Estrogen has also been reported to enhance transforming growth factor- (TGF-) signaling, which further contributes to osteoclast apoptosis and coupling between bone resorption and formation ( Studies related to runt-related transcription factor 1 (Runx1) and runt-related transcription factor 2 (Runx2) have increased the broadened our understanding of osteoblastic differentiation ( With advancing age, multiple tissues, including bone, undergo progressive structural and functional changes that contribute to organ dysfunction, and bone is no exception

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