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Additionally, Bbs5 / mice exhibited pancreatic islet hyperplasia but failed to normalize blood glucose, suggesting defective insulin action

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Because it acts on several receptor pathways at once, it is also examined in research on metabolic health and type 2 diabetes, where gastrointestinal effects are the most commonly noted observation

The clinical implications of PH in this context are substantial, yet the literature on this topic remains fragmented and inconsistent, hindering the development of standardized diagnostic and therapeutic approaches