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Preclinical studies have examined the peptide in models of gastrointestinal injury, epithelial disruption, and anastomosis healing where researchers analyze mucosal architecture, vascular integrity, and epithelial continuity following tissue damage [1]

A review in The American Journal of Medicine (2009) highlighted these risks, noting that repeated injections can lead to chronic degeneration of tendons and increased risk of soft tissue injuries

10.3748/wjg.v30.i23.2964 66 SamsonS

This may reflect progressive endothelial dysfunction or underlying disease progression rather than classical receptor desensitization alone