It also inhibits cellular death by activating the focal adhesion complex, resulting in Akt activation with wide-ranging effects on growth, survival, and motility
Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention
This oxidative damage to membrane lipids compromises membrane integrity and ultimately results in cell death
Interestingly, however, it has been determined that the activity of these enzymes can be affected by heat stress, which has the potential to shift the dynamics of the AsA-GSH cycle
