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155-157 Nighttime exposure to light, especially blue light, from electronic screens suppresses melatonin release and has been correlated with reduced sleep duration as well as lower sperm motility and concentration

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However, the metabolic and weight changes it induces can create a cascade of hormonal adjustments that manifest as menstrual irregularities

Here, we report the discovery of a series of fragment hits that bind at the interface between the TRFH domain of TRF1 (TRF1 TRFH ) and a peptide of TIN2 (TIN2 TBM ), an interaction essential for the recruitment of TRF1 to shelterin, using X-ray crystallography (XChem) and ligand-observed NMR (LO-NMR) fragment screening